UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P15209
Entry Name

NTRK2_MOUSE
Protein Name

BDNF/NT-3 growth factors receptor
Primary Gene Name

Ntrk2
Organism

Mus musculus (Mouse)
Molecular Function

Tyrosine-protein kinase
Developmental protein
Transferase
Kinase
Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name TrkB
Cell Type
Substrate Description receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4.
Substrate Function Category disease
Substrate Function Subtype
Sheddase metalloproteinase
Shedding-related Disease ischaemia
Short Summary of Papers TrkB undergoes ectodomain shedding by metalloproteinases activated after ischaemic injury or excitotoxic damage of cortical neurons, and subsequently undergoes RIP(regulated intramembrane proteolysis) .
Cleavage Information ZNo-Human:
PMID 26712630



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		32 429
Transmembrane
 		430 453



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information metalloproteinase 26712630   
PaperC No_information BACE1/2 Type I TMP proteomics 23430253   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER neuron 22728825
PAPER β-Cell 23430253