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|---|---|---|
| UniProt ID |
P15144 |
|
| Entry Name |
AMPN_HUMAN |
|
| Protein Name |
Aminopeptidase N |
|
| Primary Gene Name |
ANPEP |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Hydrolase |
|
| Membrane Location |
Cell membrane |
|
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|---|
| Substrate Name | Aminopeptidase N(CD13) | |
| Cell Type | ||
| Substrate Description | aminopeptidase, digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. marker for acute myeloid leukemia | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | cancer | |
| Short Summary of Papers | CD13 is suggested to be cleaved from plasma membrane to generate sCD13. the sCD13 activity is elevated in plasma and effusions of cancer patients and may be served as a tumor and/or angiogenesis marker. | |
| Cleavage Information | NONE | |
| PMID | 12473585 |
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|---|---|---|
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Start | End |
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9 | 32 |
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33 | 967 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | M*AKGF | 1 | unknown peptidase | physiologically relevant | N-terminal sequencing | 8102610 | ||
| PAPER | SASA*TTNP | 55 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | (unknown) | 12473585 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Milk | 16502470 | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Amniotic fluid | 17373841 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Nipple aspiration fluid | 12889602 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Tear | 16901338 | |
| Sys-BodyFluid | Urine | 11680902 | |
| Sys-BodyFluid | Urine | 16335936 | |
| Sys-BodyFluid | Urine | 16281181 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 18795103 | |
| Sys-BodyFluid | Plasma/Serum | 17877382 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Plasma/Serum | 16739989 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(pancreatic cancer) | 16215274 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(lung cancer) | 21806062 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(Lung adenocarcinoma) | 22985211 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |