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| UniProt ID |
P14784 |
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| Entry Name |
IL2RB_HUMAN |
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| Protein Name |
Interleukin-2 receptor subunit beta |
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| Primary Gene Name |
IL2RB |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Cell membrane |
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| Substrate Name | IL-2R (CD25) | |
| Cell Type | monocytes, lymphocytes | |
| Substrate Description | Leukocyte Recruitment - Cytokines and cytokine receptors involved in cell-cell communication, including firm adhesion | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; cytokine receptor | |
| Sheddase | NE(neutrophil elastase), PR3(proteinase 3), MM9 | |
| Shedding-related Disease | cytokine receptor | |
| Short Summary of Papers | prevents formation of high-affinity trimer,soluble IL-2R antagonist,immunosuppression,generates a C-terminal 37-kDa fragment, associates with STAT5A, increases cell proliferation | |
| Cleavage Information | NONE | |
| PMID | 16565325 20495002 |
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Start | End |
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27 | 240 |
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241 | 265 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | KPAA*LGKD | 235 | metallopeptidase | mutation | 20495002 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||