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| UniProt ID |
P14209 |
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| Entry Name |
CD99_HUMAN |
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| Protein Name |
CD99 antigen |
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| Primary Gene Name |
CD99 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Membrane |
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| Substrate Name | CD99 | |
| Cell Type | HeLa, Lewis lung carcinoma (LLC), human embryonic kidney (HEK)293T, and bEnd.3 cells | |
| Substrate Description | adhesion molecule | |
| Substrate Function Category | ||
| Substrate Function Subtype | ||
| Sheddase | meprin beta | |
| Shedding-related Disease | inflammation and cancer | |
| Short Summary of Papers | ectodomain shedding of CD99 is mediated by the metalloprotease meprin beta and promotes transendothelial cell migration. | |
| Cleavage Information | ||
| PMID | 28003343 |
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Start | End |
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23 | 122 |
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123 | 147 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | VAAP*DGGF | 22 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 2479542 | ||
| ASCENT | PNHP*SSSG | 84 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | NHPS*SSGS | 85 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | HPSS*SGSF | 86 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | PSSS*GSFS | 87 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | SSSG*SFSD | 88 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | SSSG*SFSD | 88 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | SSSG*SFSD | 88 | UNKNOWN | subtiligase-based N-terminal sequencing | ||||
| ASCENT | SSGS*FSDA | 89 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | SGSF*SDAD | 90 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | SGSF*SDAD | 90 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | GSFS*DADL | 91 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | SDAD*LADG | 94 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| MEROPS | ADLA*DGVS | 96 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | LCFK*ENAE | 156 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| PAPER | MESH*RNAN | 169 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | ESHR*NANA | 170 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| PMAP | No_information | gingipain K | This entry is based on an experiment | Gel electrophoresis | 16495537 | |||
| PMAP | No_information | gingipain R | This entry is based on an experiment | Gel electrophoresis | 16495537 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Cerebrospinal fluid | 15582749 | |
| Sys-BodyFluid | Urine | 11680902 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |