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| UniProt ID |
P13987 |
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| Entry Name |
CD59_HUMAN |
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| Protein Name |
CD59 glycoprotein |
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| Primary Gene Name |
CD59 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Secreted |
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| Substrate Name | protectin(CD59) | |
| Cell Type | ||
| Substrate Description | inhibitor of the complement membrane attack complex (MAC) action | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | complement inhibitor | |
| Short Summary of Papers | GPI-anchored (functionally active) protectin was shed into milk, might be a means to be targeted into cell membranes. | |
| Cleavage Information | GPI-anchor | |
| PMID | 7558140 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | SGHS*LQCY | 25 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | QLEN*GGTS | 102 | glycosylphosphatidylinositol:protein transamidase | physiologically relevant | N-terminal sequencing | 10805801 | ||
| PAPER | No_information | (unknown) | 7558140 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Milk | 16502470 | |
| Sys-BodyFluid | Milk | 12833513 | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Amniotic fluid | 17373841 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Saliva | 17614365 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Saliva | 16739998 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17853512 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Cerebrospinal fluid | 15582749 | |
| Sys-BodyFluid | Urine | 16569576 | |
| Sys-BodyFluid | Urine | 17022654 | |
| Sys-BodyFluid | Urine | 16807940 | |
| Sys-BodyFluid | Urine | 11680902 | |
| Sys-BodyFluid | Urine | 16335936 | |
| Sys-BodyFluid | Urine | 15048996 | |
| Sys-BodyFluid | Urine | 16281181 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 16739989 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer) | 22408128 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer) | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| locate | 17986452 | ||
| HCSD | cancer(colorectal cancer) | 25216327 | |