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|---|---|---|
| UniProt ID |
P13747 |
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| Entry Name |
HLAE_HUMAN |
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| Protein Name |
HLA class I histocompatibility antigen, alpha chain E |
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| Primary Gene Name |
HLA-E |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Secreted |
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|---|
| Substrate Name | HLA-E | |
| Cell Type | ||
| Substrate Description | bind to signal peptides from classical MHC class I molecules | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | metalloproteinase | |
| Shedding-related Disease | cell surface protein | |
| Short Summary of Papers | the shedding of HLA-E (by metalloproteinase) to produced a soluble form sHLA-E is a normal feature of melanocytes, but become dependent on IFN-gamma induction after metastasis. | |
| Cleavage Information | NONE | |
| PMID | 16920947 |
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|---|---|---|
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Start | End |
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22 | 305 |
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306 | 329 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | metalloproteinase | 16920947 | |||||
| PAPER | No_information | elastase, cathepsin G | 7722333 | |||||