UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P13688
Entry Name

CEAM1_HUMAN
Protein Name

Carcinoembryonic antigen-related cell adhesion molecule 1
Primary Gene Name

CEACAM1
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name CEACAM1
Cell Type
Substrate Description homophilic interactions, mediate MHC class I-independent inhibitory mechanism of human NK cytotoxicity
Substrate Function Category disease
Substrate Function Subtype
Sheddase membrane-bound metalloproteinase
Shedding-related Disease autoimmunity
Short Summary of Papers the shed soluble CEACAM1 protein blocks the CEACAM1-mediated inhibition of NK cell killing activity. the soluble CEACAM1 levels in serum among the TAP2-deficient patients is descreased.
Cleavage Information NONE
PMID 15259011



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		35 428
Transmembrane
 		429 452



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information membrane-bound metalloproteinase 15259011   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Saliva 17614365
Sys-BodyFluid Saliva 18361515
Sys-BodyFluid Tear 16901338
Sys-BodyFluid Urine 16948836
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(colorectal cancer 24418523
HCSD cancer(ovarian cancer) 22623176
HCSD cancer(Liver metastasis in colorectal cancer) 23443137