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| UniProt ID |
P13612 |
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| Entry Name |
ITA4_HUMAN |
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| Protein Name |
Integrin alpha-4 |
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| Primary Gene Name |
ITGA4 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Membrane |
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| Substrate Name | integrin alpha-4 (VLA-4) | |
| Cell Type | ||
| Substrate Description | integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | cleavage of VLA-4 is increased following T cell activation. | |
| Cleavage Information | NONE | |
| PMID | 1730718 |
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Start | End |
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35 | 977 |
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978 | 1001 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | TGRP*YNVD | 33 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 3033641 | ||
| HPRD | VISK*RSTE | 590 | 1730718 | |||||
| MEROPS | ISKR*STEE | 591 | PCSK7 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | ISKR*STEE | 591 | PCSK6 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | ISKR*STEE | 591 | PCSK4 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | ISKR*STEE | 591 | PCSK2 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | ISKR*STEE | 591 | PCSK5 peptidase | physiologically relevant | NONE | 12691605 | ||
| MEROPS | ISKR*STEE | 591 | furin | physiologically relevant | NONE | 12691605 | ||