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| UniProt ID |
P13598 |
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| Entry Name |
ICAM2_HUMAN |
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| Protein Name |
Intercellular adhesion molecule 2 |
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| Primary Gene Name |
ICAM2 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Membrane |
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| Substrate Name | ICAM-2 | |
| Cell Type | ||
| Substrate Description | ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion, mediates adhesive interactions important for antigen-specific immune response. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | metalloproteinase | |
| Shedding-related Disease | cell adhesion molecule | |
| Short Summary of Papers | cleavage of ICAM-2 by the metalloproteinase during etoposide-induced apoptosis. shedding of heavily sialylated ICAM-2 and -3 can contribute to reduced expression of sialic acid on apoptotic cells and may reduce ionic repulsion between apoptotic and phagocytic cells to provide an environment for an easier interaction between apoptotic and phagocytic cells. | |
| Cleavage Information | NONE | |
| PMID | 19524015 |
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Start | End |
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25 | 223 |
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224 | 248 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | metalloproteinase | Electrophoresis | 19524015 | ||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | platelet | 20962327 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 16739989 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |