UniProt Summary
UniProt ID

P13591

Entry Name

NCAM1_HUMAN

Protein Name

Neural cell adhesion molecule 1

Primary Gene Name

NCAM1

Organism

Homo sapiens (Human)

Molecular Function

Host cell receptor for virus entry
Receptor

Membrane Location

Secreted
Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name NCAM-1
Cell Type
Substrate Description cell migration; neurite outgrowth
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype Central nervous system (CNS) pathology; cell adhesion molecules
Sheddase metalloproteinase
Shedding-related Disease cell adhesion molecule
Short Summary of Papers shedding of NCAM regulates NCAM-mediated neurite outgrowth.
Cleavage Information NONE
PMID 15884014



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
20 718
Transmembrane
719 739



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER TAVS*LQVD 19 UNKNOWN Mass spectrometry 33796845   
ASCENT LTIY*NANI 84 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT LMFK*NAPT 121 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
PAPER LMFK*NAPT 121 UNKNOWN Mass spectrometry 33796845   
ASCENT LNGK*GLGE 592 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT SEFK*TQPV 604 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT YRAL*SSEW 652 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT GKSK*AAHF 694 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
PAPER No_information metalloproteinase 15884014   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER ovary 15815987
Sys-BodyFluid Plasma/Serum 18795103
Sys-BodyFluid Cerebrospinal fluid 17853512
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Cerebrospinal fluid 15582749
Sys-BodyFluid Plasma/Serum 18793429
Sys-BodyFluid Plasma/Serum 16104056
Sys-BodyFluid Plasma/Serum 16739989
Sys-BodyFluid Plasma/Serum 14718574
Sys-BodyFluid Cerebrospinal fluid 15952730
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Cerebrospinal fluid 17022648
HCSD cancer (lung cancer) 19776420
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(colorectal cancer 24418523
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(ovarian cancer) 22623176