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| UniProt ID |
P12830 |
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| Entry Name |
CADH1_HUMAN |
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| Protein Name |
Cadherin-1 |
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| Primary Gene Name |
CDH1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Cell membrane |
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| Substrate Name | E-cadherin | |
| Cell Type | human keratinocyte cell line HaCaT | |
| Substrate Description | cell adehison, cell migration, cell proliferation (epithelial) | |
| Substrate Function Category | development (proliferation, differentiation) | |
| Substrate Function Subtype | cell adhesion molecule | |
| Sheddase | ADAM10 | |
| Shedding-related Disease | cell adhesion molecule | |
| Short Summary of Papers | release of the extracellular domain for the regulation of cell adhesion, cell migration and cell signalling | |
| Cleavage Information | NONE | |
| PMID | 19049889 |
| Substrate Name | E-cadherin | |
| Cell Type | HEK 293 cells (Human Embryonic Kidney 293 cells) | |
| Substrate Description | cancer cell invasion, malignant progression | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | Disease: Cancers (invasion) | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | cancer (invasion,breast,prostate,gastric carcinoma.) | |
| Short Summary of Papers | cleavage of E-cadherin results in the release of soluble fragments of the extracellular domain and increased invasive behavior of cells | |
| Cleavage Information | NONE | |
| PMID | 22936788 25967040 24712279 |
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Start | End |
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155 | 709 |
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710 | 730 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | RQKR*DWVI | 154 | kallikrein-related peptidase 4 | physiologically relevant | consensus sequence | 15389820 | ||
| PAPER | RQKR*DWVI | 154 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | YTLF*SHAV | 231 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | ALPG*TSVM | 278 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | AWEA*VYTI | 411 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | LLIL*SDVN | 585 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | NONE | ||
| PMAP | LLIL*SDVN | 585 | membrane-type matrix metallopeptidase-1 | This entry is based on an experiment | N-terminal sequencing | 10597309 14729059 | ||
| MEROPS | LILS*DVND | 586 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | NONE | ||
| PMAP | LILS*DVND | 586 | membrane-type matrix metallopeptidase-1 | This entry is based on an experiment | N-terminal sequencing | 10597309 14729059 | ||
| PAPER | LKPK*MALE | 655 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | TTLE*VSVC | 682 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | GAAG*VCRK | 693 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | KAQP*VEAG | 700 | matrix metallopeptidase-7 | physiologically relevant | NONE | NONE | ||
| PMAP | KAQP*VEAG | 700 | matrix metallopeptidase-7 | This entry is based on an experiment | Others | 11595727 11953314 17504810 | ||
| MEROPS | LLFL*RRRA | 731 | presenilin 1 | physiologically relevant | NONE | 12808018 | ||
| PMAP | LLFL*RRRA | 731 | presenilin 1 | This entry is based on an experiment | 11953314 17403907 | |||
| HPRD | DTRD*NVYY | 750 | Caspase 3, apoptosis-related cysteine peptidase | 11076937 | ||||
| HPRD | DTRD*NVYY | 750 | Caspase 3, apoptosis-related cysteine peptidase | 11076937 | ||||
| PMAP | No_information | calpain-1 | This entry is based on an experiment | 12393869 | ||||
| PMAP | No_information | ADAM10 peptidase | This entry is based on an experiment | Gel electrophoresis | 18478055 | |||
| PMAP | No_information | matrix metallopeptidase-7 | This entry is based on an experiment | Gel electrophoresis | 18478055 | |||
| PMAP | No_information | meprin beta subunit | This entry is based on an experiment | Gel electrophoresis | 18478055 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | platelet | 20962327 | |
| PAPER | cancer(ovary) | 18560578 | |
| Sys-BodyFluid | Amniotic fluid | 17373841 | |
| Sys-BodyFluid | Saliva | 17614365 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Urine | 15529407 | |
| Sys-BodyFluid | Urine | 17022654 | |
| Sys-BodyFluid | Urine | 11680902 | |
| Sys-BodyFluid | Urine | 15048996 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Urine | 16335936 | |
| Sys-BodyFluid | Urine | 16281181 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 17877382 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| locate | 17986452 | ||