UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P12821
Entry Name

ACE_HUMAN
Protein Name

Angiotensin-converting enzyme
Primary Gene Name

ACE
Organism

Homo sapiens (Human)
Molecular Function

Hydrolase
Protease
Carboxypeptidase
Metalloprotease
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Angiotensin-converting enzyme (ACE)
Cell Type
Substrate Description converts angiotensin to angiotensin
Substrate Function Category enzyme
Substrate Function Subtype enzyme (carboxypeptidase)
Sheddase ADAM17
Shedding-related Disease carboxypeptidase
Short Summary of Papers generation of soluble form of ACE
Cleavage Information NONE
PMID 10187843



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		30 1256
Transmembrane
 		1257 1277



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
HPRD AGQR*LATA 1166 8253769   
HPRD AGQR*LATA 1166 8253769   
HPRD AGQR*LATA 1166 8253769   
HPRD NSAR*SEGP 1232 11485566    10769174   
HPRD NSAR*SEGP 1232 11485566    10769174   
MEROPS NSAR*SEGP 1232 ADAM17 peptidase physiologically relevant NONE NONE   
PAPER NSAR*SEGP 1232 ADAM17 NONE NONE 26554003   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Plasma/Serum 18793429
Sys-BodyFluid Plasma/Serum 14718574
Sys-BodyFluid Plasma/Serum 16739989
Sys-BodyFluid Plasma/Serum 16104056
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Seminal Fluid 16709260
Sys-BodyFluid Milk 16502470
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(colorectal cancer 24418523
HCSD cancer(Liver metastasis in colorectal cancer) 23443137
HCSD cancer(colorectal cancer) 22506683
HCSD cancer(non small cell lung cancer) 19655816
locate 17986452
HCSD cancer(lung cancer) 21806062