UniProt Summary
UniProt ID

P12318

Entry Name

FCG2A_HUMAN

Protein Name

Low affinity immunoglobulin gamma Fc region receptor II-a

Primary Gene Name

FCGR2A

Organism

Homo sapiens (Human)

Molecular Function

IgG-binding protein
Receptor

Membrane Location

Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name Fc-gamma-RIIa (CD32)
Cell Type
Substrate Description binds to the Fc region of immunoglobulins gamma
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease cell receptor
Short Summary of Papers shed soluble CD32 inhibits the binding of immune complexes to Fc gamma R+ cells
Cleavage Information NONE
PMID 8254192



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
34 217
Transmembrane
218 240



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information (unknown) 8254192   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 16739989