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| UniProt ID |
P12023 |
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| Entry Name |
A4_MOUSE |
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| Protein Name |
Amyloid-beta A4 protein |
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| Primary Gene Name |
App |
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| Organism |
Mus musculus (Mouse) |
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| Molecular Function |
Serine protease inhibitor |
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| Membrane Location |
Secreted |
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| Substrate Name | Amyloid beta A4 protein precursor (APP) | |
| Cell Type | neurons; central nervous system (CNS) | |
| Substrate Description | anti-amyloidogenic, neuroprotective (α-secretase) , amyloidogenic pathway (β-secretase) | |
| Substrate Function Category | central nervous system (neuron) | |
| Substrate Function Subtype | Central nervous system (CNS) pathology | |
| Sheddase | α-secretase(ADAM10, ADAM17), β-Secretase(BACE) | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | the shedding of APP by ADAM (α-secretase) suppress β-amyloid formation (anti-amyloidogenic, neuroprotective) | |
| Cleavage Information | NONE | |
| PMID | 22553493 18951988 |
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Start | End |
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18 | 701 |
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702 | 722 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | TVRA*LEVP | 17 | signal peptidase complex (animal) | physiologically relevant | Mass spectroscopy | 16457602 | ||
| PAPER | EVRH*QKLV | 685 | ADAM8, ADAM9, ADAM10, ADAM17, ADAM33 | 16542157 | ||||
| PaperC | No_information | BACE1 | Type I | proteomics | 22728825 | |||
| PaperC | No_information | BACE1 | Type I TMP | proteomics | 23430253 | |||