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| UniProt ID |
P11717 |
|
| Entry Name |
MPRI_HUMAN |
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| Protein Name |
Cation-independent mannose-6-phosphate receptor |
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| Primary Gene Name |
IGF2R |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Membrane |
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| Substrate Name | mannose-6-phosphate receptor (IGF2R) | |
| Cell Type | ||
| Substrate Description | transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | cell receptor (IGFR) | |
| Short Summary of Papers | shedding and release of soluble M6P/IGF II receptor fragments in biological fluids indicates may be a mechanisms contributing to the turnover of the M6P/IGF II receptor | |
| Cleavage Information | NONE | |
| PMID | 2458716 |
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Start | End |
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2305 | 2327 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | (unknown) | 2458716 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Bronchoalveolar lavage fluid | 16497942 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Tear | 16901338 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| Sys-BodyFluid | Plasma/Serum | 12917320 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(Glioblastoma) | 23483059 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |
| HCSD | cancer(lung cancer) | 21806062 | |