UniProt Summary
UniProt ID

P11627

Entry Name

L1CAM_MOUSE

Protein Name

Neural cell adhesion molecule L1

Primary Gene Name

L1cam

Organism

Mus musculus (Mouse)

Molecular Function

Developmental protein

Membrane Location

Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name L1 (neural cell adhesion molecule L1)
Cell Type CHO cells
Substrate Description cell migration; neurite outgrowth
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype Central nervous system (CNS) pathology; cell adhesion molecules
Sheddase ADAM10
Shedding-related Disease cell adhesion molecule
Short Summary of Papers shedding of L1 is necessary to promote migration.
Cleavage Information NONE
PMID 11706054 18951988



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
20 1123
Transmembrane
1124 1146



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS PCLL*IQIP 19 signal peptidase complex (animal) physiologically relevant Mass spectroscopy 16457602   
MEROPS HSKR*HIHK 863 PCSK5 peptidase physiologically relevant NONE 12529374   
PaperC No_information BACE1 Type I proteomics 22728825   
PMAP No_information presenilin 1 This_entry_is_based_on_an_experiment. Gel electrophoresis 16199880   
PMAP No_information ADAM10 peptidase This_entry_is_based_on_an_experiment. 16199880   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
PAPER β-Cell 23430253