UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P11362
Entry Name

FGFR1_HUMAN
Protein Name

Fibroblast growth factor receptor 1
Primary Gene Name

FGFR1
Organism

Homo sapiens (Human)
Molecular Function

Tyrosine-protein kinase
Transferase
Kinase
Receptor
Heparin-binding
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name FGFR1
Cell Type
Substrate Description FGFR signaling, various signals in cell proliferation, differentiation and migration
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype growth factor (FGFR)
Sheddase MMP2,
Shedding-related Disease growth factor (FGFR)
Short Summary of Papers release soluble truncated FGFR1 ectodomain that re-tained bind ability to FGF.
Cleavage Information NONE
PMID 8692946



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		22 376
Transmembrane
 		377 397



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
HPRD RPAV*MTSP 368 Matrix metalloprotease 2 8692946   
HPRD RPAV*MTSP 368 Matrix metalloprotease 2 8692946   
HPRD RPAV*MTSP 368 Matrix metalloprotease 2 8692946   
HPRD RPAV*MTSP 368 Matrix metalloprotease 2 8692946   
MEROPS RPAV*MTSP 368 matrix metallopeptidase-2 physiologically relevant NONE 8692946   
PMAP RPAV*MTSP 368 matrix metallopeptidase-2 This entry is based on an experiment 8692946   
MEROPS VSAD*SSAS 432 granzyme B (Homo sapiens-type) physiologically relevant consensus sequence 16798735   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Cerebrospinal fluid 17022648
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 17081049
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(colorectal carsinoma) 23585443
HCSD cancer(ovarian cancer) 23805888