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| UniProt ID |
P10912 |
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| Entry Name |
GHR_HUMAN |
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| Protein Name |
Growth hormone receptor |
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| Primary Gene Name |
GHR |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Secreted |
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| Substrate Name | GHR | |
| Cell Type | lymphocytes IM-9, CHO | |
| Substrate Description | growth hormone (GH) signaling | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | growth hormone receptor | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | growth hormone receptor | |
| Short Summary of Papers | circulating GH-binding protein (GHBP) generated by shedding of GHR receptor's ligand-binding extracellular domain. GHBP may function as either a potentiator (by delaying GH clearance) or an inhibitor (by GH sequestration) | |
| Cleavage Information | NONE | |
| PMID | 11309389 |
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Start | End |
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19 | 264 |
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265 | 288 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | VTLP*QMSQ | 252 | ADAM17 | NONE | 26554003 | |||
| PMAP | No_information | ADAM10 peptidase | This entry is based on an experiment | Gel electrophoresis | 17761766 | |||