UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P10747
Entry Name

CD28_HUMAN
Protein Name

T-cell-specific surface glycoprotein CD28
Primary Gene Name

CD28
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name CD28
Cell Type
Substrate Description involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
Substrate Function Category Immune and Inflammation;disease
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease cell surface protein;autoimmune disease
Short Summary of Papers soluble CD28 resulted from the shedding of the membrane form modulates the proliferation of T lymphocytes, could be associated with disease severity in patients with autoimmune disease, especially primary Sjögren's syndrome(SS).
Cleavage Information NONE
PMID 15086406



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		19 152
Transmembrane
 		153 179



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS QVTG*NKIL unknown peptidase physiologically relevant Mass spectroscopy 26796116   
PAPER No_information (unknown) 15086406   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA