UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P10721
Entry Name

KIT_HUMAN
Protein Name

Mast/stem cell growth factor receptor Kit
Primary Gene Name

KIT
Organism

Homo sapiens (Human)
Molecular Function

Kinase
Tyrosine-protein kinase
Transferase
Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Kit (SCFR, CD117)
Cell Type
Substrate Description tyrosine-protein kinase. cell-surface receptor for the KITLG/SCF
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase ADAM17
Shedding-related Disease cell receptor (SCFR)
Short Summary of Papers ADAM17 controls cell survival by regulating shedding and surface expression of c-Kit. soluble c-kit receptor may bind SCF and function as a receptor antagonist .
Cleavage Information NONE
PMID 14625290 7536489



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		26 524
Transmembrane
 		525 545



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM17 14625290   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Plasma/Serum 18793429
Sys-BodyFluid Plasma/Serum 12917320
Sys-BodyFluid Plasma/Serum 16104056
Sys-BodyFluid Plasma/Serum 17553692
Sys-BodyFluid Plasma/Serum 14718574
HCSD cancer (lung cancer) 19776420
HCSD cancer(Liver metastasis in colorectal cancer) 23443137