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| UniProt ID |
P10646 |
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| Entry Name |
TFPI1_HUMAN |
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| Protein Name |
Tissue factor pathway inhibitor |
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| Primary Gene Name |
TFPI |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Serine protease inhibitor |
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| Membrane Location |
Secreted |
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| Substrate Name | tissue factor pathway inhibitor (TFPI) | |
| Cell Type | ||
| Substrate Description | proteinase inhibitor of TF-induced coagulation. inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. | |
| Substrate Function Category | enzyme | |
| Substrate Function Subtype | ||
| Sheddase | MMP1, MMP7, MMP9, MMP12 | |
| Shedding-related Disease | proteinase inhibitor | |
| Short Summary of Papers | cleavage of TFPI by MMPs may effect TF-mediated coagulation. | |
| Cleavage Information | GPI-anchor | |
| PMID | 10859319 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | PLNA*DSEE | 28 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 15340161 | ||
| MEROPS | PPLK*LMHS | 48 | matrix metallopeptidase-1 | physiologically relevant | NONE | 10859319 | ||
| MEROPS | PPLK*LMHS | 48 | matrix metallopeptidase-8 | physiologically relevant | NONE | 12117418 | ||
| MEROPS | PPLK*LMHS | 48 | matrix metallopeptidase-9 | physiologically relevant | NONE | 10859319 | ||
| MEROPS | PPLK*LMHS | 48 | matrix metallopeptidase-7 | physiologically relevant | NONE | 10859319 | ||
| MEROPS | PPLK*LMHS | 48 | matrix metallopeptidase-12 | physiologically relevant | NONE | 10859319 | ||
| PMAP | PPLK*LMHS | 48 | matrix metallopeptidase-9 | This_entry_is_a_predicted. | 11279151 10859319 | |||
| PMAP | PPLK*LMHS | 48 | matrix metallopeptidase-12 | This_entry_is_based_on_an_experiment. | 10859319 | |||
| PMAP | PPLK*LMHS | 48 | matrix metallopeptidase-7 | This_entry_is_based_on_an_experiment. | 10859319 | |||
| PMAP | PPLK*LMHS | 48 | matrix metallopeptidase-8 | This_entry_is_based_on_an_experiment. | 12117418 | |||
| PMAP | PPLK*LMHS | 48 | matrix metallopeptidase-7 | This_entry_is_based_on_an_experiment. | N-terminal sequencing | 10859319 | ||
| PMAP | PPLK*LMHS | 48 | matrix metallopeptidase-1 | This_entry_is_based_on_an_experiment. | N-terminal sequencing | 10859319 | ||
| PMAP | PPLK*LMHS | 48 | matrix metallopeptidase-9 | This_entry_is_based_on_an_experiment. | N-terminal sequencing | 11279151 10859319 | ||
| HPRD | NANR*IIKT | 111 | Matrix metalloproteinase 12 | 10859319 | ||||
| HPRD | NANR*IIKT | 111 | Matrix metalloproteinase 12 | 10859319 | ||||
| MEROPS | NANR*IIKT | 111 | matrix metallopeptidase-12 | physiologically relevant | NONE | 10859319 | ||
| PMAP | NANR*IIKT | 111 | matrix metallopeptidase-12 | This_entry_is_based_on_an_experiment. | 10859319 | |||
| HPRD | IIKT*TLQQ | 115 | Elastase, leukocyte | 1558967 | ||||
| HPRD | IIKT*TLQQ | 115 | Elastase, leukocyte | 1558967 | ||||
| MEROPS | IIKT*TLQQ | 115 | elastase-2 | physiologically relevant | NONE | 1558967 | ||
| PMAP | IIKT*TLQQ | 115 | neutrophil elastase | This_entry_is_based_on_an_experiment. | 1558967 | |||
| HPRD | TPQS*TKVP | 202 | Matrix metalloproteinase 8; Matrix metalloproteinase 12; | 12117418 10859319 | ||||
| HPRD | TPQS*TKVP | 202 | Matrix metalloproteinase 8; Matrix metalloproteinase 12; | 12117418 10859319 | ||||
| MEROPS | TPQS*TKVP | 202 | matrix metallopeptidase-8 | physiologically relevant | NONE | 12117418 | ||
| MEROPS | TPQS*TKVP | 202 | matrix metallopeptidase-12 | physiologically relevant | NONE | 10859319 | ||
| PMAP | TPQS*TKVP | 202 | matrix metallopeptidase-12 | This_entry_is_based_on_an_experiment. | 10859319 | |||
| PMAP | TPQS*TKVP | 202 | matrix metallopeptidase-8 | This_entry_is_based_on_an_experiment. | 12117418 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| Sys-BodyFluid | Plasma/Serum | 15822942 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck cancer) | 21598386 | |
| HCSD | cancer(breast cancer) | 24505115 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |