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| UniProt ID |
P10586 |
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| Entry Name |
PTPRF_HUMAN |
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| Protein Name |
Receptor-type tyrosine-protein phosphatase F |
|
| Primary Gene Name |
PTPRF |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Hydrolase |
|
| Membrane Location |
Membrane |
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| Substrate Name | Receptor-type tyrosine-protein phosphatase F(PTPRF, LAR) | |
| Cell Type | ||
| Substrate Description | protein tyrosine phosphatase (PTP) family. dephosphorylation and signaling | |
| Substrate Function Category | enzyme | |
| Substrate Function Subtype | enzyme (receptor-like PTPases) | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | receptor-like PTPases | |
| Short Summary of Papers | shedding of LAR results in degradation and physical downregulation of activity | |
| Cleavage Information | NONE | |
| PMID | 16478662 |
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Start | End |
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30 | 1263 |
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1264 | 1284 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | GGVA*SFVC | 50 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | TATN*SLGE | 111 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | AGGN*PDPE | 161 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | GNPD*PEIS | 163 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | KQLR*SGAL | 188 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | ELSN*VVRS | 289 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | GPFQ*EVDG | 364 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | LSPF*SEYA | 382 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | SPFS*EYAF | 383 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | FSEY*AFRV | 385 | UNKNOWN | Mass spectrometry | 33796845 | |||
| ASCENT | LRVL*AFTA | 489 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | LAFT*AVGD | 492 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | FTAV*GDGP | 494 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | ITQY*SVAY | 642 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | ITQY*SVAY | 642 | UNKNOWN | Mass spectrometry | 33796845 | |||
| ASCENT | VWVR*AHTD | 685 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | VWVR*AHTD | 685 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | WVRA*HTDV | 686 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | VLVR*TDED | 702 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | GFPQ*NLHV | 920 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | TSKG*SGPL | 995 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | IQSR*TMPV | 1006 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | LQPN*TEYS | 1070 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | QPNT*EYSF | 1071 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | EYSF*VLMN | 1075 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | FVLM*NRGS | 1078 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | VRWF*YIVV | 1132 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | GEEQ*RRRR | 1173 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | RRRR*QAER | 1178 | (unkown) | N-terminal sequencing | 8089133 | |||
| PAPER | QVTP*AQQQ | 1252 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | TPAQ*QQQE | 1254 | (unkown) | N-terminal sequencing | 9245795 | |||
| PAPER | TPAQ*QQEE | 1254 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | ADAM17 | NONE | 16478662 | ||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | platelet | 20962327 | |
| PAPER | cancer(ovary) | 18560578 | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Tear | 16901338 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Lung adenocarcinoma) | 22985211 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| locate | 17986452 | ||