UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P09958
Entry Name

FURIN_HUMAN
Protein Name

Furin
Primary Gene Name

FURIN
Organism

Homo sapiens (Human)
Molecular Function

Hydrolase
Protease
Serine protease
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name furin
Cell Type
Substrate Description endoprotease activity
Substrate Function Category enzyme
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease proteinase
Short Summary of Papers furin undergoes ectodomain shedding, resulting in a soluble, secreted form protein.
Cleavage Information NONE
PMID 12220680 11237874



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		716 738



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER S-R 682 (unknown) 12220680    11237874   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Saliva 17614365
Sys-BodyFluid Saliva 18361515
Sys-BodyFluid Plasma/Serum 12917320
Sys-BodyFluid Plasma/Serum 17081049
Sys-BodyFluid Plasma/Serum 17553692
Sys-BodyFluid Plasma/Serum 14718574
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(colorectal cancer 24418523
HCSD cancer(Liver metastasis in colorectal cancer) 23443137
HCSD non-small cell lung cancer 21262398