UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P09619
Entry Name

PGFRB_HUMAN
Protein Name

Platelet-derived growth factor receptor beta
Primary Gene Name

PDGFRB
Organism

Homo sapiens (Human)
Molecular Function

Tyrosine-protein kinase
Developmental protein
Transferase
Kinase
Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name PDGFRβ
Cell Type
Substrate Description tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB
Substrate Function Category disease
Substrate Function Subtype
Sheddase ADAM10
Shedding-related Disease neurodegenerative disorders, dementia
Short Summary of Papers sPDGFRβ may be a biomarker of pericyte injury, the sPDGFRβ levels is elevated in biofluids in patients with dementia and/or other neurodegenerative disorders
Cleavage Information NONE
PMID 20529858 26407747



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		33 532
Transmembrane
 		533 553



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS ISQG*LVVT 32 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 15340161   
ASCENT RNAV*GQDT 514 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
PAPER No_information (unknown) 26407747   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Urine 16948836