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|---|---|---|
| UniProt ID |
P09603 |
|
| Entry Name |
CSF1_HUMAN |
|
| Protein Name |
Macrophage colony-stimulating factor 1 |
|
| Primary Gene Name |
CSF1 |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Cytokine |
|
| Membrane Location |
Secreted |
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|---|
| Substrate Name | CSF-1 | |
| Cell Type | macrophage, monocytes | |
| Substrate Description | hematopoietic regulation in cell survival, proliferation and differentiation | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; cytokine (hematopoietic) | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | cytokine | |
| Short Summary of Papers | shedding generate soluble CSF-1 form and regulate bioavailability of CSF-1 | |
| Cleavage Information | NONE | |
| PMID | 17982061 |
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|---|---|---|
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Start | End |
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497 | 517 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | RSIT*EEVS | 32 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 3498652 | ||
| PAPER | KKAF*LLVQ | 86 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | KAFL*LVQD | 87 | UNKNOWN | Mass spectrometry | 33796845 | |||
| ASCENT | RRSP*AEPE | 452 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | QSEG*S*S*SPQLQE | 231* | NONE | This_entry_is_based_on_an_experiment. | 8663232 9922157 | |||
| PAPER | No_information | NONE | This_entry_is_based_on_an_experiment. | 7919334 2030912 | ||||
| PMAP | No_information | NONE | This_entry_is_based_on_an_experiment. | 1733926 3264877 | ||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Bronchoalveolar lavage fluid | 11425242 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17853512 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Cerebrospinal fluid | 15582749 | |
| Sys-BodyFluid | Cerebrospinal fluid | 14998169 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| Sys-BodyFluid | Urine | 16281181 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(pancreatic cancer) | 16215274 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(breast cancer) | 24505115 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(Lung adenocarcinoma) | 22985211 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| locate | 17986452 | ||
| HCSD | cancer(colorectal cancer) | 24681409 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |