UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P09581
Entry Name

CSF1R_MOUSE
Protein Name

Macrophage colony-stimulating factor 1 receptor
Primary Gene Name

Csf1r
Organism

Mus musculus (Mouse)
Molecular Function

Kinase
Tyrosine-protein kinase
Transferase
Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name CSF1R(fms)
Cell Type macrophage, monocytes
Substrate Description hematopoietic regulation in cell survival, proliferation and differentiation
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; cytokine receptor (hematopoietic)
Sheddase ADAM17
Shedding-related Disease cytokine receptor
Short Summary of Papers shedding of CSF-1R, down-modulation in mononuclear phagocytes undergoing activation
Cleavage Information NONE
PMID 11160199



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		20 515
Transmembrane
 		516 536



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER SLGQ-SQGL 503 ADAM17 11160199    17967422    24955855   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER macrophage 24396086