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| UniProt ID |
P08F94 |
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| Entry Name |
PKHD1_HUMAN |
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| Protein Name |
Fibrocystin |
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| Primary Gene Name |
PKHD1 |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Secreted |
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|---|
| Substrate Name | Fibrocystin,Polyductin | |
| Cell Type | ||
| Substrate Description | may be required for correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly. may be a receptor protein that acts in collecting-duct and biliary differentiation. | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | ADAM | |
| Shedding-related Disease | Polycystic Kidney And Hepatic Disease | |
| Short Summary of Papers | PKHD1 protein undergoes ectodomain shedding by ADAM and RIP(regulated intramembrane proteolysis). | |
| Cleavage Information | NONE | |
| PMID | 16956880 17470460 |
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Start | End |
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24 | 3858 |
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3859 | 3879 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | ADAM | 16956880 17470460 | |||||