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| UniProt ID |
P08887 |
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| Entry Name |
IL6RA_HUMAN |
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| Protein Name |
Interleukin-6 receptor subunit alpha |
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| Primary Gene Name |
IL6R |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Secreted |
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| Substrate Name | IL-6R | |
| Cell Type | monocytes, lymphocytes | |
| Substrate Description | Leukocyte Recruitment - Cytokines and cytokine receptors involved in cell-cell communication, including firm adhesion | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; cytokine receptor | |
| Sheddase | ADAM17, Cat G(Cathepsin) | |
| Shedding-related Disease | cytokine receptor | |
| Short Summary of Papers | receptor down-regulation, soluble gp130 agonist | |
| Cleavage Information | NONE | |
| PMID | 16565325 |
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Start | End |
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20 | 365 |
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366 | 386 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | PGAA*LAPR | 19 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 2529343 | ||
| MEROPS | LPVQ*DSSS | 357 | ADAM17 peptidase | physiologically relevant | NONE | 10785383 | ||
| PMAP | LPVQ*DSSS | 357 | ADAM17 peptidase | This entry is based on an experiment | 10785383 12208655 | |||
| PAPER | No_information | ADAM17 | 18483276 | |||||
| PMAP | No_information | aminopeptidase PILS | This entry is based on an experiment | 12748171 | ||||