|
|
||
|---|---|---|
| UniProt ID |
P08637 |
|
| Entry Name |
FCG3A_HUMAN |
|
| Protein Name |
Low affinity immunoglobulin gamma Fc region receptor III-A |
|
| Primary Gene Name |
FCGR3A |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
IgG-binding protein |
|
| Membrane Location |
Secreted |
|
|
|
|---|
| Substrate Name | Fc-gamma RIIIa (CD16A) | |
| Cell Type | ||
| Substrate Description | Mediates antibody-dependent cellular cytotoxicity (ADCC) | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | ADAM17 | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | shedding of CD16 may regulate NK cell activity to prevent auto-aggressiveness or activation-induced cell death. | |
| Cleavage Information | NONE | |
| PMID | 23487023 |
|
|
|---|
|
|
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|---|---|---|
|
|
Start | End |
|
|
17 | 208 |
|
|
209 | 229 |
|
|
||||||||
|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | ADAM17 | 23487023 | |||||