UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P08588
Entry Name

ADRB1_HUMAN
Protein Name

Beta-1 adrenergic receptor
Primary Gene Name

ADRB1
Organism

Homo sapiens (Human)
Molecular Function

Receptor
G-protein coupled receptor
Transducer
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name beta-1 adrenergic receptor
Cell Type
Substrate Description G protein-coupled receptor. receptor binds epinephrine and norepinephrine. mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase metalloproteinase
Shedding-related Disease cell receptor (GPCR)
Short Summary of Papers β1-adrenergic receptor (β1AR) is cleaved by metalloproteinase. the cleavage is enhanced by agonist-mediated activation of the receptor and may represent a novel regulatory mechanism of cell-surface hβ1ARs.
Cleavage Information NONE
PMID 23066091



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		1 55
Transmembrane
 		56 84
Transmembrane
 		94 120
Extracellular
 		121 132
Transmembrane
 		133 154
Transmembrane
 		173 196
Extracellular
 		197 222
Transmembrane
 		223 248
Transmembrane
 		320 349
Extracellular
 		350 354
Transmembrane
 		355 377



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER TAAR*LLVP 31 metalloproteinase 23066091   
PAPER SPEP*LSQQ 52 metalloproteinase 23066091   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA