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|---|---|---|
| UniProt ID |
P08581 |
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| Entry Name |
MET_HUMAN |
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| Protein Name |
Hepatocyte growth factor receptor |
|
| Primary Gene Name |
MET |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Kinase |
|
| Membrane Location |
Secreted |
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| Substrate Name | Hepatocyte growth factor receptor (Met) | |
| Cell Type | HEK 293, HT1080lacZ-K15, L-CI.5s, 293T cells | |
| Substrate Description | HGF signaling (physiological processes including proliferation, scattering, morphogenesis and survival) | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | growth factor receptor (HGFR) | |
| Sheddase | ADAM10, ADAM17 | |
| Shedding-related Disease | growth factor receptor (HGFR) | |
| Short Summary of Papers | shedding of cMet by metalloproteinase regulate HGF/cMet signaling, and may invovled in cancer metastasis; soluble c-Met correlates with hepatocellular damage | |
| Cleavage Information | NONE | |
| PMID | 17875701 23746173 |
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Start | End |
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25 | 932 |
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933 | 955 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | HCIF*SPQI | 162 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | GFMF*LTDQ | 228 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | RKKR*STKK | 307 | PCSK7 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKKR*STKK | 307 | PCSK5 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKKR*STKK | 307 | PCSK6 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKKR*STKK | 307 | PCSK4 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKKR*STKK | 307 | furin | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKKR*STKK | 307 | PCSK2 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| PAPER | ILQA*AYVS | 319 | UNKNOWN | Mass spectrometry | 33796845 | |||
| ASCENT | TSIF*SYRE | 736 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | CCTT*PSLQ | 803 | UNKNOWN | Mass spectrometry | 33796845 | |||
| ASCENT | LEIK*GNDI | 861 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | No_information | ADAM10 | 17875701 | |||||
| PAPER | No_information | ADAM10,ADAM17 | 23746173 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(head and neck cancer) | 21598386 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(Glioblastoma) | 23483059 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |
| HCSD | cancer(lung cancer) | 21806062 | |