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| UniProt ID |
P08473 |
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| Entry Name |
NEP_HUMAN |
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| Protein Name |
Neprilysin |
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| Primary Gene Name |
MME |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Hydrolase |
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| Membrane Location |
Cell membrane |
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| Substrate Name | Neprilysin (NEP,MME, CALLA) | |
| Cell Type | ||
| Substrate Description | neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones. | |
| Substrate Function Category | enzyme | |
| Substrate Function Subtype | ||
| Sheddase | ADAM17 | |
| Shedding-related Disease | peptidase | |
| Short Summary of Papers | ADAM17 mediated release of the soluble Neprilysin. | |
| Cleavage Information | NONE | |
| PMID | 24495806 |
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Start | End |
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29 | 51 |
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52 | 750 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | QEPK*TEDI | 126 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | AVQK*AKAL | 135 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| PAPER | No_information | ADAM17 | 24495806 | |||||