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| UniProt ID |
P08253 |
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| Entry Name |
MMP2_HUMAN |
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| Protein Name |
72 kDa type IV collagenase |
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| Primary Gene Name |
MMP2 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Hydrolase |
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| Membrane Location |
Secreted |
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| Substrate Name | MMP2 | |
| Cell Type | ||
| Substrate Description | metalloproteinase mediate ectodomain shedding | |
| Substrate Function Category | enzyme | |
| Substrate Function Subtype | ||
| Sheddase | MT1-MMP | |
| Shedding-related Disease | protease | |
| Short Summary of Papers | shedding of MMP2 results in the activation of MMP2 | |
| Cleavage Information | NONE | |
| PMID | 8663332 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PMAP | APSP*IIKF | 33 | MT-MMP | This_entry_is_based_on_an_experiment. | Others | 10356396 | ||
| PMAP | AVQY*LNTF | 53 | MT-MMP | This_entry_is_based_on_an_experiment. | Others | 10356396 | ||
| PMAP | YLNT*FYGC | 56 | MT-MMP | This_entry_is_based_on_an_experiment. | Others | 10356396 | ||
| HPRD | ESCN*LFVL | 66 | Matrix metalloproteinase 14; Matrix metalloproteinase 25; | 8663332 14583471 | ||||
| MEROPS | ESCN*LFVL | 66 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | 8663332 | ||
| MEROPS | ESCN*LFVL | 66 | membrane-type matrix metallopeptidase-6 | physiologically relevant | NONE | 14583471 | ||
| PMAP | ESCN*LFVL | 66 | membrane-type matrix metallopeptidase-6 | This_entry_is_based_on_an_experiment. | 14583471 | |||
| PMAP | ESCN*LFVL | 66 | membrane-type matrix metallopeptidase-1 | This_entry_is_based_on_an_experiment. | N-terminal sequencing | 8663332 11889136 16026329 8939968 8621565 | ||
| PMAP | ESCN*LFVL | 66 | MT-MMP | This_entry_is_based_on_an_experiment. | Others | 10356396 | ||
| PMAP | KMQK*FFGL | 79 | MT-MMP | This_entry_is_based_on_an_experiment. | Others | 10356396 | ||
| PMAP | FGLP*QTGD | 84 | MT-MMP | This_entry_is_based_on_an_experiment. | Others | 10356396 | ||
| MEROPS | QTGD*LDQN | 88 | matrix metallopeptidase-2 | physiologically relevant | Mass spectroscopy | 20305283 | ||
| MEROPS | ETMR*KPRC | 98 | trypsin-2 type A | physiologically relevant | NONE | 9261109 | ||
| MEROPS | RKPR*CGNP | 101 | PCSK2 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKPR*CGNP | 101 | PCSK4 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKPR*CGNP | 101 | PCSK6 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKPR*CGNP | 101 | PCSK5 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKPR*CGNP | 101 | PCSK7 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKPR*CGNP | 101 | furin | physiologically relevant | consensus sequence | 15637056 | ||
| PMAP | RKPR*CGNP | 101 | furin | This_entry_is_based_on_an_experiment. | Gel electrophoresis | 15637056 | ||
| HPRD | DVAN*YNFF | 109 | Matrix metalloproteinase 25 | 14583471 | ||||
| MEROPS | DVAN*YNFF | 109 | matrix metallopeptidase-2 | physiologically relevant | NONE | 8269931 | ||
| MEROPS | DVAN*YNFF | 109 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | 8621565 | ||
| MEROPS | DVAN*YNFF | 109 | membrane-type matrix metallopeptidase-6 | physiologically relevant | NONE | 14583471 | ||
| PMAP | DVAN*YNFF | 109 | membrane-type matrix metallopeptidase-6 | This_entry_is_based_on_an_experiment. | 14583471 | |||
| PMAP | DVAN*YNFF | 109 | matrix metallopeptidase-2 | This_entry_is_based_on_an_experiment. | N-terminal sequencing | 1317162 8530478 8663332 1313744 2071592 15280448 14583633 | ||
| PMAP | DVAN*YNFF | 109 | membrane-type matrix metallopeptidase-1 | This_entry_is_based_on_an_experiment. | N-terminal sequencing | 8621565 | ||
| PMAP | DVAN*YNFF | 109 | MT-MMP | This_entry_is_based_on_an_experiment. | Others | 10356396 | ||
| MEROPS | YRII*GYTP | 129 | matrix metallopeptidase-2 | physiologically relevant | Mass spectroscopy | 20305283 | ||
| MEROPS | RAFQ*VWSD | 149 | matrix metallopeptidase-2 | physiologically relevant | Mass spectroscopy | 20305283 | ||
| MEROPS | RFSR*IHDG | 161 | matrix metallopeptidase-2 | physiologically relevant | Mass spectroscopy | 20305283 | ||
| MEROPS | LLAH*AFAP | 193 | matrix metallopeptidase-2 | physiologically relevant | Mass spectroscopy | 20305283 | ||
| MEROPS | AFAP*GTGV | 197 | matrix metallopeptidase-2 | physiologically relevant | Mass spectroscopy | 20305283 | ||
| MEROPS | VGGD*SHFD | 204 | matrix metallopeptidase-2 | physiologically relevant | Mass spectroscopy | 20305283 | ||
| MEROPS | PETA*MSTV | 336 | elastase-2 | physiologically relevant | NONE | 7619826 | ||
| PMAP | PETA*MSTV | 336 | neutrophil elastase | This_entry_is_based_on_an_experiment. | Gel electrophoresis | 7619826 | ||
| MEROPS | FLGN*KYES | 358 | matrix metallopeptidase-2 | physiologically relevant | Mass spectroscopy | 20305283 | ||
| MEROPS | LGNK*YESC | 359 | matrix metallopeptidase-2 | physiologically relevant | Mass spectroscopy | 20305283 | ||
| MEROPS | ATTA*NYDD | 379 | elastase-2 | physiologically relevant | NONE | 7619826 | ||
| PMAP | ATTA*NYDD | 379 | neutrophil elastase | This_entry_is_based_on_an_experiment. | Gel electrophoresis | 7619826 | ||
| MEROPS | LGPV*TPEI | 464 | elastase-2 | physiologically relevant | NONE | 7619826 | ||
| PMAP | LGPV*TPEI | 464 | neutrophil elastase | This_entry_is_based_on_an_experiment. | Gel electrophoresis | 7619826 | ||
| MEROPS | PEIC*KQDI | 469 | matrix metallopeptidase-2 | physiologically relevant | Mass spectroscopy | 20305283 | ||
| MEROPS | KNKK*TYIF | 579 | matrix metallopeptidase-2 | physiologically relevant | Mass spectroscopy | 20305283 | ||
| PMAP | No_information | membrane-type matrix metallopeptidase-2 | This_entry_is_based_on_an_experiment. | Others | 16469749 | |||
| PMAP | No_information | streptopain | This_entry_is_based_on_an_experiment. | Gel electrophoresis | 8890235 | |||
| PMAP | No_information | matrix metallopeptidase-22 | This_entry_is_based_on_an_experiment. | Gel electrophoresis | 9651395 | |||
| PMAP | No_information | plasmin | This_entry_is_based_on_an_experiment. | Gel electrophoresis | 12764090 | |||
| PMAP | No_information | membrane-type matrix metallopeptidase-4 | This_entry_is_based_on_an_experiment. | Gel electrophoresis | 10551873 | |||
| PMAP | No_information | membrane-type matrix metallopeptidase-2 | This_entry_is_based_on_an_experiment. | Gel electrophoresis | 7559440 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 15952730 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Plasma/Serum | 16739989 | |
| Sys-BodyFluid | Plasma/Serum | 16083276 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(colorectal cancer) | 22506683 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| locate | 17986452 | ||
| HCSD | cancer(colorectal cancer) | 24681409 | |
| HCSD | cancer(lung cancer) | 21806062 | |