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| UniProt ID |
P08174 |
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| Entry Name |
DAF_HUMAN |
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| Protein Name |
Complement decay-accelerating factor |
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| Primary Gene Name |
CD55 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Host cell receptor for virus entry |
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| Membrane Location |
Secreted |
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| Substrate Name | Decay accelerating factor (DAF, CD55) | |
| Cell Type | ||
| Substrate Description | GPI-anchor glycoprotein, protect host cells from inadvertent autolysis by the complement system | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | cell surface protein | |
| Short Summary of Papers | DAF was proteolytically cleaved and a large extracellular domain of DAF (soluble DAF) was released | |
| Cleavage Information | NONE | |
| PMID | 2477368 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | AVWG*DCGL | 34 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 1712233 | ||
| MEROPS | GTTS*GTTR | 353 | glycosylphosphatidylinositol:protein transamidase | physiologically relevant | N-terminal sequencing | 12675719 | ||
| PAPER | No_information | (unknown) | 2477368 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Amniotic fluid | 17373841 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Urine | 16335936 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 17877382 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(colorectal cancer) | 22506683 | |