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| UniProt ID |
P08069 |
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| Entry Name |
IGF1R_HUMAN |
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| Protein Name |
Insulin-like growth factor 1 receptor |
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| Primary Gene Name |
IGF1R |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Kinase |
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| Membrane Location |
Cell membrane |
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| Substrate Name | IGF1R | |
| Cell Type | ||
| Substrate Description | receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | ||
| Sheddase | metalloprotease | |
| Shedding-related Disease | cell receptor (IGFR) | |
| Short Summary of Papers | IGF1R were cleavages by metalloprotease and γ-Secretases(regulated intramembrane proteolysis) sequentially. the intracellular domain (ICD) may mediate a function independent of its role as a receptor tyrosine kinase | |
| Cleavage Information | NONE | |
| PMID | 17524361 |
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Start | End |
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741 | 935 |
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936 | 959 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | PTSG*EICG | 30 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 2877871 | ||
| PAPER | No_information | metalloprotease | 17524361 | |||||