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| UniProt ID |
P07911 |
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| Entry Name |
UROM_HUMAN |
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| Protein Name |
Uromodulin |
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| Primary Gene Name |
UMOD |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Secreted |
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| Substrate Name | Tamm-Horsfall protein (uromodulin) | |
| Cell Type | ||
| Substrate Description | biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH). promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes | |
| Substrate Function Category | renal | |
| Substrate Function Subtype | ||
| Sheddase | Carboxypeptidase Y | |
| Shedding-related Disease | urine | |
| Short Summary of Papers | urinary THP is a proteolytic product released from the membrane-bound GPI-anchored precursor in the kidney. | |
| Cleavage Information | GPI-anchor | |
| PMID | 11741296 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | QGRF*SVQM | 548 | Carboxypeptidase Y | 11741296 | ||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Urine | 16569576 | |
| Sys-BodyFluid | Urine | 17022654 | |
| Sys-BodyFluid | Urine | 16807940 | |
| Sys-BodyFluid | Urine | 11680902 | |
| Sys-BodyFluid | Urine | 16335936 | |
| Sys-BodyFluid | Urine | 15048996 | |
| Sys-BodyFluid | Urine | 16281181 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 16739989 | |