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| UniProt ID |
P07359 |
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| Entry Name |
GP1BA_HUMAN |
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| Protein Name |
Platelet glycoprotein Ib alpha chain |
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| Primary Gene Name |
GP1BA |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Membrane |
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| Substrate Name | GPIbα | |
| Cell Type | platelet | |
| Substrate Description | ||
| Substrate Function Category | disease | |
| Substrate Function Subtype | Disease: thrombus formation regulation | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | thrombus formation | |
| Short Summary of Papers | shear-induced interaction of platelets with immobilized VWF results in GPIbα ectodomain shedding | |
| Cleavage Information | NONE | |
| PMID | 19820200 |
| Substrate Name | GPIbα | |
| Cell Type | platelet | |
| Substrate Description | platelet hemostasis | |
| Substrate Function Category | blood and homoeostasis | |
| Substrate Function Subtype | platelet; platelet glycoprotein | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | platelet (cell surface protein) | |
| Short Summary of Papers | releases glycocalicin to the plasma, mediate clearance of stored platelets | |
| Cleavage Information | NONE | |
| PMID | 24119228 |
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Start | End |
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17 | 531 |
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532 | 552 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | PLHP*HPIC | 16 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 3497398 | ||
| MEROPS | DTDL*YDYY | 291 | cathepsin G | physiologically relevant | NONE | 7980408 | ||
| PMAP | DTDL*YDYY | 291 | cathepsin G | This entry is based on an experiment | N-terminal sequencing | 7980408 8400294 11520793 | ||
| MEROPS | TDLY*DYYP | 292 | cathepsin G | physiologically relevant | NONE | 11520793 | ||
| PMAP | TDLY*DYYP | 292 | cathepsin G | This entry is based on an experiment | N-terminal sequencing | 7980408 11520793 | ||
| MEROPS | YPEE*DTEG | 298 | najalysin | not physiologically relevant | NONE | NONE | ||
| MEROPS | YPEE*DTEG | 298 | mocarhagin | not physiologically relevant | NONE | NONE | ||
| MEROPS | RTVV*KFPT | 312 | cathepsin G | physiologically relevant | NONE | 7980408 | ||
| PAPER | LRGV*LQGH | 507 | ADAM10 | NONE | Synthetic peptides | 17445093 | ||
| PAPER | No_information | ADAM17 | NONE | Gel electrophoresis | 16179345 | |||
| PMAP | No_information | neutrophil elastase | This entry is based on an experiment | Gel electrophoresis | 2933256 | |||