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| UniProt ID |
P07355 |
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| Entry Name |
ANXA2_HUMAN |
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| Protein Name |
Annexin A2 |
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| Primary Gene Name |
ANXA2 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
RNA-binding |
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| Membrane Location |
Secreted |
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| Substrate Name | annexin II | |
| Cell Type | ||
| Substrate Description | calcium-regulated membrane-binding protein. | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | MMP7 | |
| Shedding-related Disease | cancer (invasion) | |
| Short Summary of Papers | 35 kDa annexin II was released via proteolytic cleavage by MMP7. the cleavage of cell surface annexin II by MMP7 contributes to tumor invasion and metastasis by enhancing tPA-mediated pericellular proteolysis by cancer cells. | |
| Cleavage Information | NONE | |
| PMID | 18721140 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | M*STVH | 1 | unknown peptidase | physiologically relevant | N-terminal sequencing | NONE | ||
| MEROPS | ILCK*LSLE | 10 | matrix metallopeptidase-7 | physiologically relevant | NONE | 18721140 | ||
| MEROPS | LSLE*GDHS | 14 | glutamyl peptidase I | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | GSVK*AYTN | 28 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | IKTK*GVDE | 49 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | GVDE*VTIV | 53 | glutamyl peptidase I | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | LTNR*SNAQ | 63 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | LASA*LKSA | 86 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | LKSA*LSGH | 90 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | LSGH*LETV | 94 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | GHLE*TVIL | 96 | glutamyl peptidase I | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | GLLK*TPAQ | 104 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | ASMK*GLGT | 119 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | ICSR*TNQE | 135 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | EINR*VYKE | 145 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | DLEK*DIIS | 157 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | GDFR*KLMV | 168 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | LVQC*IQNK | 262 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | FADR*LYDS | 273 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | ovary | 15815987 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 17877382 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Urine | 16807940 | |
| Sys-BodyFluid | Tear | 16901338 | |
| Sys-BodyFluid | Saliva | 16103422 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Saliva | 17614365 | |
| Sys-BodyFluid | Bronchoalveolar lavage fluid | 16497942 | |
| Sys-BodyFluid | Amniotic fluid | 17373841 | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(Glioblastoma) | 21601021 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(breast cancer) | 24505115 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(gastric cancer) | 22204653 | |
| HCSD | cancer(Lung adenocarcinoma) | 22985211 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| locate | 17986452 | ||