|
|
||
|---|---|---|
| UniProt ID |
P07204 |
|
| Entry Name |
TRBM_HUMAN |
|
| Protein Name |
Thrombomodulin |
|
| Primary Gene Name |
THBD |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Receptor |
|
| Membrane Location |
Membrane |
|
|
|
|---|
| Substrate Name | thrombomodulin | |
| Cell Type | ||
| Substrate Description | cell receptor, forms complex with thrombin. activation of protein C.coagulation mechanism. | |
| Substrate Function Category | blood and homoeostasis | |
| Substrate Function Subtype | ||
| Sheddase | serine protease | |
| Shedding-related Disease | thrombin, coagulation | |
| Short Summary of Papers | extracellular redox state plays a crucial role in the regulation of thrombomodulin shedding and the generation of activated protein C. | |
| Cleavage Information | NONE | |
| PMID | 20605193 |
|
|
|---|
|
|
||
|---|---|---|
|
|
Start | End |
|
|
19 | 515 |
|
|
516 | 539 |
|
|
||||||||
|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | LGFP*APAE | 18 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 2820710 | ||
| PAPER | No_information | serine protease | 20605193 | |||||
|
|
|||
|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Urine | 16335936 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| locate | 17986452 | ||
| HCSD | cancer(colorectal cancer) | 24681409 | |