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| UniProt ID |
P07174 |
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| Entry Name |
TNR16_RAT |
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| Protein Name |
Tumor necrosis factor receptor superfamily member 16 |
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| Primary Gene Name |
Ngfr |
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| Organism |
Rattus norvegicus (Rat) |
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| Molecular Function |
Developmental protein |
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| Membrane Location |
Cell membrane |
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| Substrate Name | p75NTR (NGFR,TNFRSF16) | |
| Cell Type | ||
| Substrate Description | diverse signaling in survival and apoptosis | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | growth factor receptor (neurotrophin) | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | growth factor receptor (NGFR) | |
| Short Summary of Papers | ectodomain shedding result in RIP (regulated intramembrane proteolysis), regulate cell apoptosis | |
| Cleavage Information | NONE | |
| PMID | 14638693 17904861 |
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Start | End |
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30 | 253 |
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254 | 274 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | SSQP*VVTR | 242 | ADAM10 peptidase | physiologically relevant | NONE | 15701642 | ||
| PMAP | SSQP*VVTR | 242 | ADAM10 peptidase | Mass spectrometry | 15701642 | |||
| MEROPS | PVVT*RGTT | 245 | ADAM10 peptidase | physiologically relevant | NONE | 15701642 | ||
| PMAP | PVVT*RGTT | 245 | ADAM10 peptidase | Mass spectrometry | 15701642 | |||
| PAPER | No_information | ADAM17 | Gel electrophoresis | 14638693 | ||||
| PMAP | No_information | presenilin 1 | Gel electrophoresis | 15701642 | ||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||