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| UniProt ID |
P06804 |
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| Entry Name |
TNFA_MOUSE |
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| Protein Name |
Tumor necrosis factor |
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| Primary Gene Name |
Tnf |
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| Organism |
Mus musculus (Mouse) |
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| Molecular Function |
Cytokine |
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| Membrane Location |
Secreted |
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| Substrate Name | TNF-α | |
| Cell Type | endothelial cell, monocytes, lymphocytes, neutrophils | |
| Substrate Description | Leukocyte Recruitment, Chemokine recruitment of leukocytes | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; cytokine | |
| Sheddase | ADAM17, MMP-7 PR3(proteinase 3) | |
| Shedding-related Disease | cytokine | |
| Short Summary of Papers | generate soluble TNF antagonist whichdown-regulate mTNF signaling | |
| Cleavage Information | NONE | |
| PMID | 16565325 |
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Start | End |
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36 | 56 |
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57 | 235 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | SSMA*QTLT | 75 | ADAM8,ADAM9,ADAM10,ADAM17,ADAM19 | NONE | 16542157 | |||
| PMAP | QTLT*LRSS | 79 | NONE | 7629174 | ||||
| PAPER | TLRS*SSQN | 82 | ADAM8,ADAM9,ADAM10,ADAM17,ADAM19 | NONE | 16542157 | |||