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| UniProt ID |
P06756 |
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| Entry Name |
ITAV_HUMAN |
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| Protein Name |
Integrin alpha-V |
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| Primary Gene Name |
ITGAV |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Host cell receptor for virus entry |
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| Membrane Location |
Cell membrane |
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| Substrate Name | integrin alpha-v | |
| Cell Type | ||
| Substrate Description | receptors for a wide array of ligands such as vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | MT1-MMP | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | the cleavage of pro-αv by MT1-MMP suggested a novel mechanism in the regulation of integrin functionality by MT1-MMP. heat shock-induced shedding of cell surface integrins alpha v beta 3 | |
| Cleavage Information | NONE | |
| PMID | 11741954 7505747 |
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Start | End |
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31 | 992 |
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993 | 1016 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | LCRA*FNLD | 30 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 2467745 | ||
| ASCENT | YSIK*YNNQ | 233 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| MEROPS | ITKR*DLAL | 890 | furin | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | ITKR*DLAL | 890 | PCSK2 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | ITKR*DLAL | 890 | PCSK4 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | ITKR*DLAL | 890 | PCSK6 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | ITKR*DLAL | 890 | PCSK5 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | ITKR*DLAL | 890 | PCSK7 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | TKRD*LALS | 891 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | 11741954 | ||
| ASCENT | YSLK*SSAS | 951 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |