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| UniProt ID |
P06734 |
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| Entry Name |
FCER2_HUMAN |
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| Protein Name |
Low affinity immunoglobulin epsilon Fc receptor |
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| Primary Gene Name |
FCER2 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Secreted |
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| Substrate Name | CD23 (Low affinity IgE Fc receptor) | |
| Cell Type | B cell lines | |
| Substrate Description | immunoglobulin signaling and immune response | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; receptor (immunoglobulin) | |
| Sheddase | ADAM8, ADAM15, ADAM10, ADAM28, ADAM33 | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | proteolytic release of soluble CD23, result in up-regulation of IgE production and the induction of inflammatory cytokines | |
| Cleavage Information | NONE | |
| PMID | 19049889 26538900 |
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Start | End |
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22 | 47 |
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48 | 321 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | DQMA*QKSQ | 80 | ADAM8 peptidase | not physiologically relevant | NONE | 17389606 | ||
| MEROPS | DQMA*QKSQ | 80 | ADAM10 peptidase | not physiologically relevant | NONE | 17389606 | ||
| PMAP | DQMA*QKSQ | 80 | ADAM8 peptidase | This_entry_is_based_on_an_experiment. | Mass spectrometry | 17389606 | ||
| PMAP | DQMA*QKSQ | 80 | ADAM10 peptidase | This_entry_is_based_on_an_experiment. | Mass spectrometry | 17389606 | ||
| MEROPS | LRAE*QQRL | 98 | ADAM8 peptidase | not physiologically relevant | NONE | 17389606 | ||
| PMAP | LRAE*QQRL | 98 | ADAM8 peptidase | This_entry_is_based_on_an_experiment. | Mass spectrometry | 17389606 | ||
| MEROPS | RAEQ*QRLK | 99 | ADAM8 peptidase | not physiologically relevant | NONE | 17389606 | ||
| MEROPS | RAEQ*QRLK | 99 | ADAM10 peptidase | not physiologically relevant | NONE | 17389606 | ||
| PMAP | RAEQ*QRLK | 99 | ADAM10 peptidase | This_entry_is_based_on_an_experiment. | Mass spectrometry | 17389606 | ||
| PMAP | RAEQ*QRLK | 99 | ADAM8 peptidase | This_entry_is_based_on_an_experiment. | Mass spectrometry | 17389606 | ||
| MEROPS | EQQR*LKSQ | 101 | ADAM10 peptidase | not physiologically relevant | NONE | 17389606 | ||
| PMAP | EQQR*LKSQ | 101 | ADAM10 peptidase | This_entry_is_based_on_an_experiment. | Mass spectrometry | 17389606 | ||
| MEROPS | GSAE*SMGP | 298 | peptidase 1 (mite) | physiologically relevant | NONE | NONE | ||
| PMAP | No_information | ADAM15 peptidase | This_entry_is_based_on_an_experiment. | Mass spectrometry | 12777399 | |||
| PMAP | No_information | ADAM28 peptidase | This_entry_is_based_on_an_experiment. | Mass spectrometry | 12777399 | |||