UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P06729
Entry Name

CD2_HUMAN
Protein Name

T-cell surface antigen CD2
Primary Gene Name

CD2
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name CD2
Cell Type
Substrate Description interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. triggering of T-cells
Substrate Function Category disease
Substrate Function Subtype
Sheddase elastase, cathepsin G
Shedding-related Disease cystic fibrosis
Short Summary of Papers cleavage of lymphocyte surface antigens CD2 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis, may lead to a temporary state of immunologic unresponsiveness in chronic inflammation in CF patients
Cleavage Information NONE
PMID 7722333



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		25 209
Transmembrane
 		210 235



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information elastase, cathepsin G 7722333   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
HCSD cancer(colorectal carsinoma) 23585443