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|---|---|---|
| UniProt ID |
P06213 |
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| Entry Name |
INSR_HUMAN |
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| Protein Name |
Insulin receptor |
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| Primary Gene Name |
INSR |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Kinase |
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| Membrane Location |
Cell membrane |
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| Substrate Name | Insulin receptor | |
| Cell Type | ||
| Substrate Description | receptor tyrosine kinasemediates the pleiotropic actions of insulin. | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | MMP | |
| Shedding-related Disease | diabetes | |
| Short Summary of Papers | soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes | |
| Cleavage Information | NONE | |
| PMID | 17563065 |
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|---|---|---|
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Start | End |
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28 | 758 |
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763 | 956 |
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957 | 979 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | GAAG*HLYP | 27 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 2983222 | ||
| MEROPS | RKRR*SLGD | 762 | PCSK7 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKRR*SLGD | 762 | PCSK5 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKRR*SLGD | 762 | PCSK6 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKRR*SLGD | 762 | PCSK2 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKRR*SLGD | 762 | PCSK4 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKRR*SLGD | 762 | furin | physiologically relevant | NONE | 7929288 | ||
| PAPER | No_information | MMP | 17563065 | |||||