UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P06127
Entry Name

CD5_HUMAN
Protein Name

T-cell surface glycoprotein CD5
Primary Gene Name

CD5
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name CD5
Cell Type
Substrate Description may act as a receptor in regulating T-cell proliferation.
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease cell receptor
Short Summary of Papers natural soluble CD5 form is released by proteolytic cleavage of the membrane form, representing proteolytic release of a transmembrane SRCR (Scavenger Receptor Cysteine-Rich) family member following cell activation.
Cleavage Information NONE
PMID 10488739



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		25 372
Transmembrane
 		373 402



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS SCLG*RLSW unknown peptidase physiologically relevant Mass spectroscopy 26796116   
PAPER No_information (unknown) 10488739   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA