UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P05981
Entry Name

HEPS_HUMAN
Protein Name

Serine protease hepsin
Primary Gene Name

HPN
Organism

Homo sapiens (Human)
Molecular Function

Hydrolase
Protease
Serine protease
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name hepsin
Cell Type human hepatoma HepG2 cells, and SMMC-7721 cells
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase calpain-1
Shedding-related Disease cancer metastasis
Short Summary of Papers hepsin is cleaved extracellularly at Tyr52.
Cleavage Information
PMID 31395734



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		24 44
Extracellular
 		45 417



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
HPRD PVDR*IVGG 162 12962630   
HPRD PVDR*IVGG 162 12962630   
MEROPS PVDR*IVGG 162 hepsin physiologically relevant NONE 15839837   
PMAP PVDR*IVGG 162 hepsin This entry is based on an experiment N-terminal sequencing 15839837   
HPRD VDRI*VGGR 163 12962630   
HPRD VDRI*VGGR 163 12962630   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Urine 16948836