UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P05622
Entry Name

PGFRB_MOUSE
Protein Name

Platelet-derived growth factor receptor beta
Primary Gene Name

Pdgfrb
Organism

Mus musculus (Mouse)
Molecular Function

Tyrosine-protein kinase
Developmental protein
Transferase
Kinase
Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name PDGFRβ
Cell Type
Substrate Description tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB
Substrate Function Category disease
Substrate Function Subtype
Sheddase ADAM10
Shedding-related Disease neurodegenerative disorders, dementia
Short Summary of Papers sPDGFRβ may be a biomarker of pericyte injury, the sPDGFRβ levels is elevated in biofluids in patients with dementia and/or other neurodegenerative disorders
Cleavage Information NONE
PMID 20529858 26407747



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		32 531
Transmembrane
 		532 552



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM10 20529858   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA