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| UniProt ID |
P05556 |
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| Entry Name |
ITB1_HUMAN |
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| Protein Name |
Integrin beta-1 |
|
| Primary Gene Name |
ITGB1 |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Host cell receptor for virus entry |
|
| Membrane Location |
Cell membrane |
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| Substrate Name | integrin beta-1 | |
| Cell Type | ||
| Substrate Description | integrins are heterodimeric proteins made up of alpha and beta subunits. membrane receptors involved in cell adhesion and recognition in a variety of processes. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | MMP2 | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | MMP2 cleavage Integrin-β1 ectodomain facilitates colon cancer cell motility. | |
| Cleavage Information | NONE | |
| PMID | 22898815 |
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Start | End |
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21 | 728 |
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729 | 751 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| ASCENT | LKKK*GCPP | 73 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | YSGK*FCEC | 551 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | TTVV*NPKY | 791 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | MMP2 | 22898815 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(pancreatic cancer) | 16215274 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(gastric cancer) | 22204653 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |
| HCSD | cancer(lung cancer) | 21806062 | |