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| UniProt ID |
P05106 |
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| Entry Name |
ITB3_HUMAN |
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| Protein Name |
Integrin beta-3 |
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| Primary Gene Name |
ITGB3 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Host cell receptor for virus entry |
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| Membrane Location |
Postsynaptic cell membrane |
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| Substrate Name | integrin beta-3 | |
| Cell Type | ||
| Substrate Description | receptors for a wide array of ligands such ascytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | heat shock-induced shedding of cell surface integrins alpha v beta 3 | |
| Cleavage Information | NONE | |
| PMID | 7505747 |
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Start | End |
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27 | 718 |
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719 | 741 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | VGVG*GPNI | 26 | signal peptidase complex (animal) | physiologically relevant | Mass spectroscopy | 12665801 | ||
| PAPER | VSPM*CAWC | 48 | UNKNOWN | Mass spectrometry | 33796845 | |||
| HPRD | EERA*RAKW | 761 | Calpain, large polypeptide L1 | 7592818 | ||||
| MEROPS | EERA*RAKW | 761 | calpain-1 | physiologically relevant | NONE | 7592818 | ||
| PMAP | EERA*RAKW | 761 | calpain-1 | This entry is based on an experiment | 7592818 | |||
| PMAP | EERA*RAKW | 761 | calpain-1 | This entry is based on an experiment | N-terminal sequencing | 7592818 | ||
| HPRD | KWDT*ANNP | 767 | Calpain, large polypeptide L1 | 7592818 | ||||
| MEROPS | KWDT*ANNP | 767 | calpain-1 | physiologically relevant | NONE | 7592818 | ||
| PMAP | KWDT*ANNP | 767 | calpain-1 | This entry is based on an experiment | 7592818 | |||
| PMAP | KWDT*ANNP | 767 | calpain-1 | This entry is based on an experiment | N-terminal sequencing | 7592818 | ||
| HPRD | NPLY*KEAT | 773 | Calpain, large polypeptide L1 | 7592818 | ||||
| MEROPS | NPLY*KEAT | 773 | calpain-1 | physiologically relevant | NONE | 7592818 | ||
| PMAP | NPLY*KEAT | 773 | calpain-1 | This entry is based on an experiment | 7592818 | |||
| PMAP | NPLY*KEAT | 773 | calpain-1 | This entry is based on an experiment | N-terminal sequencing | 7592818 | ||
| HPRD | TSTF*TNIT | 780 | Calpain, large polypeptide L1 | 7592818 | ||||
| MEROPS | TSTF*TNIT | 780 | calpain-1 | physiologically relevant | NONE | 7592818 | ||
| PMAP | TSTF*TNIT | 780 | calpain-1 | This entry is based on an experiment | 7592818 | |||
| PMAP | TSTF*TNIT | 780 | calpain-1 | This entry is based on an experiment | N-terminal sequencing | 7592818 | ||
| HPRD | NITY*RGT | 785 | Calpain, large polypeptide L1 | 7592818 | ||||
| MEROPS | NITY*RGT | 785 | calpain-1 | physiologically relevant | NONE | 7592818 | ||
| PMAP | NITY*RGT | 785 | calpain-1 | This entry is based on an experiment | 7592818 | |||
| PMAP | NITY*RGT | 785 | calpain-1 | This entry is based on an experiment | N-terminal sequencing | 7592818 | ||
| PAPER | No_information | (unknown) | 7505747 | |||||
| PMAP | No_information | cathepsin G | This entry is based on an experiment | Gel electrophoresis | 8400294 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | platelet | 20962327 | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(lung cancer) | 21186846 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |